Erratum: Loss of Environmental Enrichment Increases Vulnerability to Cocaine Addiction

Reversal of cocaine addiction by environmental enrichment.

Environmental conditions can dramatically influence the behavioral and neurochemical effects of drugs of abuse. For example, stress increases the reinforcing effects of drugs and plays an important role in determining the vulnerability to develop drug addiction. On the other hand, positive conditions, such as environmental enrichment, can reduce the reinforcing effects of psychostimulants and m...

Molecular Mechanisms Underlying Environmental Enrichment-Induced Neuroprotection in Vulnerability to Nicotine Addiction

Environmental deterioration increases tadpole vulnerability to predation.

Human-induced environmental change is occurring at an unprecedented rate and scale. Many freshwater habitats, in particular, have been degraded as a result of increased salinity. Little is known about the effects of anthropogenic salinization on freshwater organisms, especially at sublethal concentrations, where subtle behavioural changes can have potentially drastic fitness consequences. Using...

Shared vulnerability between seizures and psychosis in cocaine addiction?

Cocaine-induced seizures (CIS) and cocaine-induced psychosis (CIP) may be complications of acute cocaine intoxication. CIS could result from a kindling process, involving the glutamate NMDA receptor (NMDAR) phosphorylation state, which is enhanced by activation of the dopamine D1 receptor (D1R). CIP is considered to be more specifically associated with the activity of the dopamine D2 receptor (...

Responses to novelty and vulnerability to cocaine addiction: contribution of a multi-symptomatic animal model.

Epidemiological studies have revealed striking associations between several distinct behavioral/personality traits and drug addiction, with a large emphasis on the sensation-seeking trait and the associated impulsive dimension of personality. However, in human studies, it is difficult to identify whether personality/behavioral traits actually contribute to increased vulnerability to drug addict...